Thus, curcumin and luteolin impair the migratory activity in tumor cells by the repression of the CXCL12/CXCR4 biological axis, as a consequence of the downregulation of MMP-9 by luteolin (Qin et al., 2018; Bu and Zhao, 2020). The gene discussed is CXCL12; the disease is neoplasm.