TOP2A and glioblastoma: In the copy number variation (CNV) differential analysis between normal and GBM, we found that there were significant differences in the 12 hub genes, which were CDCA8, KIF2C, NUF2, ECT2, LMNB1, KIFC1, NONO, RBMX, CDCA5, TMEM97, TOP2A, and AURKA (Figure 5D).