The association of cytosolic β-catenin with E-cadherin at adherens junctions stabilizes E-cadherin expression in epithelial cells and the structure of intercellular junctions (Nelson and Nusse, 2004; Voronkov and Krauss, 2013), and play crucial roles in epidermal and HF development, stem cell renewal, and tissue homeostasis. Here, CDH1 is linked to hydrops fetalis.