To investigate the impact of SGK1 on fetal programming and hypertension (blood pressure), Rexhepaj et al., mated wild-type (sgk1+/+) male mice with sgk1–/– female mice, and sgk1–/– males with sgk1+/+ females, resulting in heterozygotic (sgk1–/+) offspring in both cases (Rexhepaj et al., 2008). The gene discussed is SGK1; the disease is hypertensive disorder.