Other syndromic disorders include Loeys-Dietz syndrome (LDS) and vascular Ehlers-Danlos syndrome (vEDS) which are caused by mutations in the TGF-β signaling cascade (Lindsay et al., 2012) and in COL3A1 (Pepin et al., 2000), respectively. This evidence concerns the gene COL3A1 and Ehlers-Danlos syndrome, vascular type.