In addition, we previously reported that CD147 induces cell proliferation and invasion by activating pSTAT3Y705 signaling via interacting with CD44s (Li et al., 2013), while anti-CD147 inhibits CSC potential and sensitizes cancer cells to chemoradiotherapy by blocking CD44s-pSTAT3 signaling (Fan et al., 2019). Here, BSG is linked to cancer.