When assuming the threshold of twofold change (i.e., log2 fold change (FC) > 1), we have identified following 11 genes fulfilling this criterium in at least one MPS type: UCHL1, FBXO38, TRIM25, CUL4A, VCP, SPOP, PSMD2, PSMD13, PSMB8, PSMB9, PSME2, HSPB1, and ADRM1 (Table 3; with detailed statistical analysis shown in Supplementary Table 3). The gene discussed is PSMD2; the disease is mucopolysaccharidosis.