To further verify whether circ_0088233 as a ceRNA of miR-185-3p, we investigated its effect on the level of circ_0088233 knockdown on the levels of WNT2B and E2F1, which are the targets of miR-185-3p identified in cancer cells (Liu et al., 2017; Lu et al., 2018). The gene discussed is WNT2B; the disease is cancer.