For instance, rat sarcoma (RAS)-wild-type CRC was successfully treated with epidermal growth factor receptor (EGFR) monoclonal antibodies while human epidermal growth factor receptor 2 (HER2) high expression gastric cancer was managed in patients using the HER2 monoclonal antibody trastuzumab (Van Schaeybroeck et al., 2011; Gomez-Martín et al., 2014). Here, ERBB2 is linked to colorectal carcinoma.