In HGPS patients, there is a heterozygous mutation in <i>LMNA</i> gene, in which there is a deletion of genetic codes responsible for 50 amino acids at the C-terminus of prelamin A. The processing of the abnormal prelamin A results in abnormal lamin A protein, called progerin, causing symptoms of accelerated early aging, probably due to the inflammaging process. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.