In a study which was conducted to determine the effect of apigenin in human colorectal carcinoma HCT116 cells, it was shown that treatment with this flavone (0–50 μM) potentially inhibits cell growth through inducing cell arrest at the G2/M phase; it is associated with the suppression of the expression level of both cyclin B1 as well as both Cdc2 and Cdc25c which are cyclin B1 activating partners, and also an increase of the expression level of cell cycle inhibitors, p53 and p21WAF1/CIP1 (Lee et al., 2014). Here, CCNB1 is linked to colorectal carcinoma.