It is worth noting that the level of AChE in the brain declines to 55–67%, while BChE increases to 120% of normal levels during the progressed AD, indicating that BChE plays a critical role for ACh hydrolysis in the late stage of AD (Greig et al., 2001; Mushtaq et al., 2014). The gene discussed is BCHE; the disease is Alzheimer disease.