• Asthma symptoms   • New chest radiography changes   • Serum total IgE >500 IU/mL or four-fold increase in IgE titers   • Raised specific IgE aspergillus RAST or positive skin prick test to A. fumigatus   • Blood eosinophil count >500/mm3   • Positive Aspergillus culture in sputum or fungal hyphae. This evidence concerns the gene IGHE and asthma.