Figure 3, adapted from (78), depicts a patient with typical Weaver syndrome feature who was found to have a variant in EED gene. WLS, the rarest of the autosomal dominant PRC2-related overgrowth syndrome, does not include the characteristic camptodactyly, abnormal tone (either hypertonia or hypotonia) and microretrognathia seen in WS. Intellectual disability has been reported in one out of three published cases (74). This evidence concerns the gene EED and Weaver syndrome.