Similarly, in Weaver syndrome, non-congenital overexpression of the DNA methyltransferase EZH2 is found in several solid tumors and non-Hodgkin lymphoma, a change that serves as a negative prognostic factor (82), yet germline variants in this gene causing Weaver syndrome are not linked to an increased risk of those tumors. Here, EZH2 is linked to Weaver syndrome.