PRC2 is comprised of three core subunits, encoded by the genes EZH2, SUZ12, and EED. Variants in the latter two components are known to cause Weaver-like syndrome (WLS, OMIM 618786) (74, 75) and Cohen–Gibson syndrome (COGIS, OMIM 617561) (76), respectively. The gene discussed is SUZ12; the disease is Cohen-Gibson syndrome.