CYCS and infection: Further on, mitochondrial permeabilization and cytochrome c release in Chlamydia-infected cells is blocked in the initial phases of infection (Fan et al., 1998), but in the absence of Bax an Bak C. trachomatis is still able to cause nuclear fragmentation, indicative of cell death induction, at the end of infection cycle (Ying et al., 2006).