The therapeutic efficacy with micafungin in aspergillosis is strictly induced by the activation of the TLR2/dectin-1 and TLR3/TRIF signaling pathways, which regulate the inflammatory/anti-inflammatory balance during infection, mainly by increasing the production of IL-10 and decreased TNF-α (Moretti et al., 2014). The gene discussed is IL10; the disease is aspergillosis.