Human peripheral blood mononuclear cells (PBMCs) that carry L412F after interaction with C. albicans have a reduction in the production of TNF-α, type I IFN and IFN-γ (Nahum et al., 2012), these cytokines are extremely important for maintaining the innate and adaptive response against candidiasis (Gozalbo and Gil, 2009), this low production can strengthen the susceptibility of part of the patients with CMCC to infection with C. albicans (Nahum et al., 2012). The gene discussed is TNF; the disease is infection.