Higher levels of afucosylated Fc IgG1 isoforms, which have an enhanced capacity to engage with the activating FcRIIIA, was associated with DHF and shock in those with acute dengue suggesting antibody binding to FcγRIIIA is likely to be associated with severe disease (Wang et al., 2017). The gene discussed is FCGR3A; the disease is Dengue hemorrhagic fever.