In a dual transcriptome analyses of the host and parasite genes in samples from 46 malaria-infected Gambian children, Lee et al. (2018) performed multivariate analyses and showed association of disease severity with increased expression of granulopoiesis and IFN-γ related genes as well as inadequate suppression of IFN-I signaling (Lee et al., 2018). This evidence concerns the gene IFNG and malaria.