CXCL8 and gastric cancer: The role of ICEs in gastric cancer pathogenesis could be associated to inflammation induction in the gastric epithelium (Waskito et al., 2018) because T4SS encoded by these elements promotes the induction of interleukin 8 independent from the presence of cag-PAI (Kersulyte et al., 2009), reinforced when the determinant is present (Silva et al., 2017).