Recent evidence also indicates that MM-specific cytotoxic CD8+ T cells do not express CD28 and express low levels of programmed cell death-1 (PD-1), cytotoxic T lymphocyte antigen-4 (CTLA-4), lymphocyte-activation gene 3 (LAG3), and T cell immunoglobulin-3 (TIM-3) (35). This evidence concerns the gene CD8A and Miyoshi myopathy.