TAMs also contribute to MM-associated neovascularization by vasculogenic mimicry and indirectly by secreting a wide range of proangiogenic factors, such as vascular endothelial growth factor (VEGF), IL-8, and fibroblast growth factor-2 (FGF-2) as well as metalloproteinases (MMPs), cycloxygenase-2 (COX-2), and colony-stimulating factor-1 (CSF-1). This evidence concerns the gene VEGFA and Miyoshi myopathy.