Increased levels of inflammatory cytokines, such as IL-1, IL-6, IL-12, IL-15, IL-17, IL-18, IL-22, IL-23, TNF-α, and IFN-γ have been revealed in BM serum of MM patients (135), and an eight-gene signature (IL-8, IL-10, IL-17, CCL3, CCL5, VEGFA, EBI3, and NOS2) involved in B-cell inflammation has been described able to distinguish the different phases of disease progression (MGUS/smoldering/symptomatic-MM) with 84% accuracy (134). Here, NOS2 is linked to Miyoshi myopathy.