Within the universal tumor antigens, many myeloma-associated antigens (e.g. human telomerase reverse transcriptase (hTERT) (19), surviving (20), new york esophageal squamous cell carcinoma 1 (NY-ESO1) (21) mucin-1 (MUC-1) (22), junctional adhesion molecule-A (JAM-A) (23, 24) and the receptor for hyaluronic acid-mediated motility (RHAMM) (25) have been identified as targets recognized by T lymphocytes and used in many vaccination strategies, but in most cases failed to produce clinically meaningful responses. The gene discussed is MUC1; the disease is esophagitis.