✧ ZAP-70 enhances BCR signaling upon IgM activation; ✧ Interactions with BCR-related proteins; ✧ ZAP-70 correlates with CCR7, CXCR4 expression and enhanced cell migration; ✧ Modulation of TLR-induced response through mediating SYK activation, IgM secretion, and Bim degradation; ✧ Associates with CCL3 and CCL4 secretion and T cell infiltration in the tumor microenvironment. Here, ZAP70 is linked to neoplasm.