CASP8 and cancer: Intriguingly, DHA has already been proven to have promising antitumor effects in various cancer types via inhibiting TGF-β, AKT, and STAT3 pathways and promoting the cleavage of caspases-8 and caspases-3 and downregulating the expression of anti-apoptosis protein Bcl-2 (30, 31, 37, 39, 40).