One study based on a randomized multicentre phase 3 trial (MITO2) found that carboplatin/PLD might be more effective than carboplatin/paclitaxel to ovarian cancer patients in the presence of pACC overexpression, suggesting that ACC might be a new biomarker for personalizing the choice of chemotherapy regimen in ovarian cancer (52). The gene discussed is ACACA; the disease is ovarian cancer.