Hypermethylation and epigenetic silencing has also be observed for several other important tumor suppressor genes such as tissue factor pathway inhibitor 2 (TFPI-2) (63), death-associated protein kinase (DAPK) (64), cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), HOXD10, FGFR2, ITIH5, and RASAL3 in B-cell lymphoma (65–67). Here, CDKN2A is linked to B-cell non-Hodgkin lymphoma.