The extensive roles of miRNAs in vulvar carcinoma have also been recently investigated by Yang et al., who suggested that miR−4712−5p may promote carcinogenesis by targeting PTEN and could facilitate VSCC growth and invasion through the alteration of the PTEN/Akt/p−GSK3β/cyclin D1 signaling pathway (231). This evidence concerns the gene PTEN and vulvar carcinoma.