GWAS studies identified several NB susceptibility loci (Table 3) including CASC15 (160), BARD1 (157), LMO1 (175), HACE1, and LIN28B (155) associated with high-risk NB, whereas DUSP12, HSD17B12, DDX4, and IL31RA associated with the low-risk NB group (161, 198). The gene discussed is HACE1; the disease is neuroblastoma.