In different studies, pathogenic and likely pathogenic variants were identified in predisposition genes such as ALK, CHEK2, BRCA2, SMARCA4, and TP53 (Table 1) but also in candidate genes like AXIN2, PALB2, BARD1, PINK1, APC, BRCA1, SDHB, and LZTR1 (2, 135, 146, 196, 197, 200) Specifically, TP53 variants are strongly associated with NB susceptibility (201). This evidence concerns the gene ALK and neuroblastoma.