IDO1 and neoplasm: Besides, targeting glutamine metabolism with JHU-083 inhibits both tumor growth and metastasis in an immune-dependent manner, including inhibiting infiltration of myeloid-derived suppressor cells, reprogramming myeloid-derived suppressor cells and tumor-associated macrophages from a suppressive to a proinflammatory phenotype, increasing immunogenic cell death and antigen presentation, and reducing kynurenine levels in both tumor and myeloid-derived cells by inhibiting IDO expression, which in turn inhibited the development of metastasis and further enhanced antitumor immunity (107).