found that cancer associated fibroblast (CAF) synthesize glutamine in glutamine-deficient tumor microenvironment to maintain glutamine-addicted ovarian cancer cell growth, where targeting glutamine synthetase in tumor stroma could reduce tumor weight and metastasis in orthotopic ovarian carcinoma mouse model, and the treatment effect can be further enhanced by co-targeting glutaminase in cancer cells (109). The gene discussed is GLS; the disease is ovarian carcinoma.