The results of this work show, for the first time, that two transcription factors, YY1 and KLF4, which are known to participate in the pathogenesis of NHL, and also have been proposed as targets for pharmacological inhibitors as a potential alternative treatment (15), are regulated by miR-7, which can modulate the capacity of NHL cells for proliferation, migration and chemoresistance. This evidence concerns the gene KLF4 and non-Hodgkin lymphoma.