Western blotting of liver, pancreas, and tumor protein extracts from mice bearing the PaCa xenografts also showed the 220+ kDa band in all three PaCa models and not in the normal hepatic and pancreatic tissue, indicating elevated EDB-FN expression in the tumors and no expression in the normal tissues and organs (Figure 3B). The gene discussed is FN1; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.