In hepatocellular carcinoma, the lncRNAs phosphatase and tensin homolog pseudogene 1 (PTENP1) activate autophagy, interacting with miR-17, miR-19b, and miR-20a, denying their targeting of the autophagy genes ULK1, ATG7 and p62/SQSTM1, and the tumor suppressor PTEN. This evidence concerns the gene PTENP1 and hepatocellular carcinoma.