LGR5 and neoplasm: Our data also supported that the biofunctions of ARL4C/JAK2/STAT5/β-catenin axis were carried out by a set of molecules, such as Axin2, CD44, Ccnd1, Lgr-5, and MMP7. Axin2 is responsible for the stability of β-catenin (28); CD44 is a famous stem cell marker and adhesion molecule to enhance the proliferation, migration, and invasion (29); Ccnd1 enhances the proliferation of cancer cells via promoting the cell's G1/S transition (30); Lgr-5 is a biomarker for stem cells, involved in tumor development (31).