NOS2 and cholangiocarcinoma: For example, while NF-κB O-GlcNAcylation promotes MMP-mediated migration and invasive capability of CCA cells (55), NF-κB p65 O-GlcNAcylation downregulates C-X-C chemokine receptor 4 (CXCR4) to inhibit cervical cancer (CESC) cell metastasis to the lungs (56), and NF-κB activation-mediated upregulation of inducible nitric oxide synthase (iNOS) modulates immune suppression and tumor progression (57, 58).