In ovarian cell lines expressing wild-type p53, the high level of OGT/O-GlcNAcylation can stabilize the tumor suppressor p53, and stabilized p53 further promotes the acquisition of new pro-oncogenic activities including cell proliferation and metabolic changes, whereas the stabilization of p53 was not detected in cell lines with mutated p53 (36, 37), indicating a role of O-GlcNAcylation in regulating ovarian cancer proliferation and progression. Here, TP53 is linked to ovarian cancer.