RELA and breast cancer: In breast cancer cells, one of the most common NF-κB dimeric forms, RELA (p65)/p50, can be O-GlcNAcylated at Thr322 and Thr352 residues of p65, which competitively inhibits p65 Ser536 phosphorylation, thus facilitating activated NF-κB-mediated gene transcription (52–54).