Recently, it was demonstrated that OGT can O-GlcNAcylate Notch1, a process enhanced by glucosamine, resulting in the cleavage and nuclear translocation of Notch1 (51), thereby regulating the transcription of target genes, suggesting the importance of Notch1 transcriptional activity in cancer metastasis by modulating its O-GlcNAcylation. The gene discussed is NOTCH1; the disease is cancer.