Among the frequently altered were other known tumor-related genes such as PTEN (25%), TP53 (24%), CDC27 (23%), ZFHX3 (22%), MUC16 (20%), ARID1A (18%), KMT2C (15%), KRAS (9%), and BRCA2 (9%). The gene discussed is ZFHX3; the disease is neoplasm.