The recurrently amplified regions include genes encoding retinal proteins FAM138D (12p13.33) and FAM138E (15q26.3), while the recurrently deleted regions include tumor-suppressor genes, e.g., DOCK8 and KANK1, as well as genes that participate in interferon alpha/beta (IFN-α/β) signaling (IRF7, IFITM1/2/3/5). The gene discussed is FAM138E; the disease is neoplasm.