VHL and neoplasm: ctDNA was detected in 18 late-stage or mRCC patients (53%) with a median of 2 GAs per patient. VHL (n = 5) and TP53 (n = 7) were the most frequent GAs.Patients with detectable ctDNA had significantly higher tumor size (8.81 vs. 4.49 cm; P = 0.04)