16 proteins increased >1.5-fold and 14 proteins decreased <0.67-fold in RCC patients compared to controls.Quantification by western blot showed that HSC71 was significantly upregulated in RCC sera (P = 0.0037)HSC71 was elevated in RCC sera when measured with ELISA (P = 0.0028 vs. control, P = 0.0008 vs. non-RCC) and showed diagnostic value (AUC = 0.86 and 87% sensitivity at 80% specificity). Here, HSPA8 is linked to renal cell carcinoma.