Proteomic analysis was performed on 9 urinary exosome pooled samples and led to the identification of 261 proteins from control samples and 186 from RCC patient samples.Most of the identified proteins are membrane associated or cytoplasmicA panel of 10 proteins (CD10, CP, DPEP1, MMP9, EMMPRIN, CAIX, Syntenin 1, PODXL, AQP1, DKK4) that were differently abundant in tumor and normal EVs were validated by immunoblotting. This evidence concerns the gene DKK4 and renal cell carcinoma.