lncRNAs showed differential abundance: 13 lncRNAs were down-regulated and 1 lncRNAs was up-regulated in ccRCC serum. The signature of lncRNA-LET, PVT1, PANDAR, PTENP1 and linc00963 was highly specific and sensitive in discriminating between ccRCC and controlsThis 5-lncRNA signature was also correlated with all pathological stages of ccRCC (AUC = 0.85 and 0.8 for stage I and II-IV, respectively). This evidence concerns the gene PVT1 and nonpapillary renal cell carcinoma.