High levels of soluble LAG3 were associated with an increased risk of advanced disease (OR = 3.36, P = 0.002)High soluble PD-L2 concentration correlated with an increased risk of disease recurrence (HR = 2.51, P = 9.33 × 10−4)Patients with high soluble BTLA and high soluble TIM3 showed an increased risk of tumor-related death (6-fold increase) and decreased OS (log-rank P = 9.81 × 10−8 and log-rank P = 6.29 × 10−5, respectively). This evidence concerns the gene PDCD1LG2 and neoplasm.