AKT1 and central nervous system cancer: By supplementing cells with exogenous H2O2, NF-κB and ERK were activated in these three cell lines; the STAT3 pathway was inhibited in glioma U87 and LN229 cell lines while activated in the THP-1 cell, whereas the AKT pathway was activated in the U87 and THP-1 cell lines but inhibited in LN229 cell line (Figure 5C).