Comparison of the transcription levels of the seven prognostic-associated TBC genes with the TCGA melanoma dataset showed that the relative mRNA expression of 5 gens (TBC1D10C, TBC1D19, TBC1D16, TBC1D13 and TBC1D7) were significantly upregulated, 1 (TBC1D15) was significantly downregulated, while 1 (TBC1D8B) was comparable in the SKCM as compared with the normal tissues (Supplementary Figure 2A). This evidence concerns the gene TBC1D19 and melanoma.