Different from the study by Qi et al., we investigated the association of mRNA expression of TBCs and the clinical traits in melanoma, and we observed that in spite of TBC1D7, six other prognostic-associated TBC genes TBC1D13, TBC1D16, TBC1D7, TBC1D8B, TBC1D15, TBC1D19, and TBC1D10C were also identified by LASSO Cox regression analysis In addition, mutations profile of these genes was also analyzed. The gene discussed is TBC1D16; the disease is melanoma.