We also investigated the correlation of the seven prognostic-associated TBCs between MMP-related genes (MMP2, MMP9, MMP7, MMP14, BSG, EGFR, MMP1, MMP3) and EMT-associated genes (TWIST1, VIM, CDH2, ACTA2, ZEB1), which also indicated a central role of TBCs in melanoma. The gene discussed is CDH2; the disease is melanoma.