Numerous genes have been identified that are silenced by focal DNA hypermethylation in meningiomas include TIMP3, TP73, MEG3, GSTP1, several homeobox (HOX) family members (HOXA7, HOXA9, HOXA10 HOXA6 and HOXA9), CDKN2A, WNK, TMEM30B, and MAL2 (91). This evidence concerns the gene MEG3 and meningioma.