FH and esophageal squamous cell carcinoma: For both sexes, a positive FH was most frequently recalled by the MPC cases (43.8% and 55.2%), and for patients with upper-, middle-, and lower-third ESCC and GCA, the percentage was 35.1%, 28.2%, 29.5%, 24.4% and 26.7%, 25.0%, 24.3%, and 22.3% sex-specifically (Table 2).