These included hematologic toxicity (anemia, thrombocytopenia, neutropenia), gastrointestinal toxicity (diarrhea, nausea, vomiting), fatigue, increases of alanine aminotransferase and aspartate aminotransferase, decreased appetite, and dehydration observed more frequently in the abemaciclib arm. The gene discussed is GPT; the disease is anemia (phenotype).