Mir-137 can inhibit the migration and invasion of melanoma cells 45–47 by targeting various mRNAs such as PIK3R3, TBX3, c-Met, YB1, EZH2, and MITF (47–49), and inhibit the proliferation and promote the apoptosis of melanoma cells by competitive binding to genes such as SLC1A5, GLO1, CDK6, etc. (50–52). The gene discussed is PIK3R3; the disease is melanoma.