The four hub mRNAs (FKBP4, RCC1, GBP1, and PRADC1), one miRNA (hsa-mir-137), and seven lncRNAs (HCP5, SNHG14, FGD5-AS1, HCG18, MAGI2-AS3, OIP5-AS1, and TUG1) in ceRNA network play important roles in the development of melanoma and other various tumors and are widely involved in the immune regulation process. The gene discussed is PDS5B; the disease is melanoma.