Consistent with this result, Qiu et al. reported that REG3A was a tumor suppressor in gastric cancer, while REG3A overexpression could inhibit the invasion and proliferation and promote the apoptosis of gastric cancer cells via the phosphatidylinositol 3-kinase (PI3K)/Akt-GSK3 signaling pathway axis (31). Here, AKT1 is linked to gastric cancer.