We found that 14 proteins (hCG, TUFM, HSPA4, RRBP1, RPS3, PGK1, PRKDC, COL12A1, GDI2, IARS2, DHX9, GLA, UGDH, and NAMPT) were specifically up-regulated in IBC tissues, and 23 proteins (PIP, APOD, KRT2, APOA2, KRT6E, IL16, AZGP1,HBA2, KRT5, HBG1, ITIH2, SPTBN1, COL18A1,SERPINA4, PEBP1, APOL1, GGT5, MAOB, ITGB4,EHD2, APCS, ITGB1, and PTN) were specifically down-regulated in IBC tissues. Here, COL12A1 is linked to inflammatory breast carcinoma.