Step-changing proteins were identified in DCIS compared with cancer-adjacent and normal tissues, including increased expression of STAM, ARF5, ANXA6, SCPEP1, ME2, and WFS1 (Supplementary Table 6), and decreased expression of KRT1, KRT10, KRT6E, APOA1, DSP, LUM, ANK1, and F2 in DCIS tissues (Supplementary Table 6). The gene discussed is ME2; the disease is cancer.