We found that 14 proteins (hCG, TUFM, HSPA4, RRBP1, RPS3, PGK1, PRKDC, COL12A1, GDI2, IARS2, DHX9, GLA, UGDH, and NAMPT) were specifically up-regulated in IBC tissues, and 23 proteins (PIP, APOD, KRT2, APOA2, KRT6E, IL16, AZGP1,HBA2, KRT5, HBG1, ITIH2, SPTBN1, COL18A1,SERPINA4, PEBP1, APOL1, GGT5, MAOB, ITGB4,EHD2, APCS, ITGB1, and PTN) were specifically down-regulated in IBC tissues. The gene discussed is RRBP1; the disease is inflammatory breast carcinoma.