In the immunohistochemical analysis of specimens from gastric cancer, lung adenocarcinoma, primary OSCC, prostate cancer, and esophageal cancer, CNTN1 expression was significantly positively associated with lymphatic invasion, metastasis, late TNM stage, and a short overall survival time (9, 12, 13, 16, 18, 22–25). This evidence concerns the gene CNTN1 and esophageal cancer.