Previous studies have determined the role of CNTN1 in neurogenesis, Alzheimer’s disease (42), multiple sclerosis (43, 44), and chronic inflammatory demyelinating polyneuropathy (45, 46) as a neuronal cell adhesion molecule and a component of septate-like junctions between the terminal myelin loops and axolemma (47). This evidence concerns the gene NRCAM and early-onset autosomal dominant Alzheimer disease.