HLA-C and central nervous system cancer: We also found that risk scores were correlated positively with the expressions of the immune checkpoint (B7-H3, CTLA4, LAG3, PD-1, PD-L1, PD-L2, and TIM-3) (Figures 9B,E) and inflammatory factors (HLA-A, HLA-B, and HLA-C) by using Pearson correlation analysis in TCGA and CGGA cohorts (Figures 9C,F), indicating that the risk scores are also positively associated with an elevated level of immune exhaustion and that the immune-related gene signature might promote activation of inflammatory responses in glioma patients.