Chio et al. reported that treatment of temozolomide (TMZ)-resistant human glioma cells with honokiol can reduce cell activity and induce apoptosis, and Zhang et al. (27) showed that ARG MAPK8IP1 overexpression and SH3GLB1 knockdown inhibited glioma cell progression and improved TMZ sensitivity. This evidence concerns the gene SH3GLB1 and central nervous system cancer.