Mitotic kinases, such as Aurora kinase A (AURKA) and Polo-like kinase 1 (PLK1), are reported to stabilize MYCN by inhibiting the Fbxw7-mediated degradation of the MYCN protein (40–42) and may promote SCD in MYCN-amplified neuroblastoma cells (Figure 1). The gene discussed is PLK1; the disease is neuroblastoma.