In the present study, we demonstrated that high FBLN2 immunoexpression was significantly associated with aggressive UTUC and UBUC characteristics, such as high tumor stage and grade, PNI, VI, lymph node metastasis, and high mitotic rate, suggesting important roles of FBLN2 in UC progression and metastasis. The gene discussed is FBLN2; the disease is renal pelvis/ureter urothelial carcinoma.