We assessed HERV-K env and HERV-K pol transcription as well as HERV-K Env and HERV-K Pol protein expression in the surgical specimens (tumor and normal tissues) of seven patients with advanced-stage colon cancer (Stage IIIA, IIIB, IIIC, IVA, or IVB). Here, ERVW-1 is linked to colonic neoplasm.