We instead focused on human colon cancer and assessed the HERV-H, -K (HML-2), and -P LTR methylation status; HERV-H, -K (HML-2), -P env, and HERV-K (HML-2) pol transcription; and HERV-K Env and Pol protein expression in surgical specimens collected from a population of patients with advanced-stage disease, and the results for the tumor samples were compared to those for normal tissues. This evidence concerns the gene ERVW-1 and neoplasm.