ERVFRD-1 and colonic neoplasm: Considering the specific role of Syncytin-1 and Syncytin-2 in pregnancy and the intrinsic fusogenic potential of the HERV Env protein in general (37, 38), but also taking into account that we did not characterize the expressed proteins, we may only suppose that it may be involved in colon cancer development or progression and represent a potential target for immunotherapy (36).