Furthermore, APC (p < 0.0001), ASXL1 (p < 0.0001), DNMT3B (p = 0.001), PARP4 (p = 0.002), MET (p = 0.01), TOP1 (p = 0.01), KDR (p = 0.01), SRC (p = 0.01), PAK1 (p = 0.015), ALK (p = 0.02), and MYC (p = 0.03) alterations were found to be more common in tumor samples from AO mCRC patients. Here, TOP1 is linked to neoplasm.