Some researchers have shown that in pancreatic cancer, FBW7 regulates the nucleoside transporter protein (ENT1) at the protein level rather than at the transcriptional level to promote chemosensitivity to gemcitabine and may therefore be a feasible target for improving the efficacy of chemotherapy in pancreatic cancer (86). The gene discussed is SLC29A1; the disease is familial pancreatic carcinoma.