IFNG and cancer: Additionally, copy-number alterations (CNAs) linked to DNA damage response and regulation of DNA editing/repair gene expression were shown to emanate from the malignant exposure to IFN-γ-secreting antigen-specific CTLs in vivo, implying that intensified genetic instability could be among the mechanisms through which CTLs and IFN-γ immunoedits cancers, changing their immune resistance due to genetic evolution (82).